Purine nucleotides
Cambridge Isotope Laboratories ADENOSINE 13C10 98 1SN10MG
Adenosine (13C10, 98%; 1sN5, 96-98%), 10mg
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 g/mol | C22H29N5O9P2 | 1 ML
Motesanib diphosphate is the diphosphate salt of motesanib (AMG 706), a potent ATP-competitive inhibitor of VEGFR1/2/3. It is supplied for research and analytical use to prepare concentrated stock solutions and for use as a reference standard in biochemical and cell-based assays.
- Research reagent for kinase inhibition assays.
- High purity, 99.9% (reported by supplier).
- CAS number 857876-30-3 and molecular weight 569.44 g/mol.
- Provided to support preparation of 1, 5, and 10 mM stock solutions.
- Common pack sizes listed for preparation include 1 mg, 5 mg, and 10 mg.
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Sigma Aldrich Fine Chemicals Biosciences Coenzyme A trilithium salt25MG
Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.2% | 512.15 | 50 MG
Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate that features inosine as its nucleobase. This compound is known for its role in intracellular energy metabolism and signal transduction processes.
- A purine ribonucleoside 5'-diphosphate
- Inosine is the nucleobase
- Participates in intracellular energy metabolism
- Involved in signal transduction processes
- Relevant to respiratory disease research
- Applicable to metabolic or endocrine disease studies
- Used in pulmonary disease research
- Investigated in lung fibrosis studies
- Can be classified as an oligonucleotide
- Functions as a nucleotide analog
- Related to inosine compounds
- Identified as a nucleoside
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.17% | 512.15 | 500 MG
Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate with inosine as the nucleobase. It participates in intracellular energy metabolism and signal transduction processes.
- Purine ribonucleoside 5'-diphosphate
- Contains inosine as the nucleobase
- Participates in intracellular energy metabolism
- Involved in signal transduction processes
TARGETMOL CHEMICALS INC GUANOSINE 5-DIPHOSPHATE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. purity: 98%
Alkali Scientific Coenzyme A Trilithium Salt, 100 Milligrams
Coenzyme A Trilithium Salt is a key biochemical cofactor used in metabolic studies and enzyme catalysis. This 100mg reagent plays a critical role in various biochemical reactions, particularly in the synthesis and metabolism of fatty acids, cholesterol, and other lipids. Coenzyme A is involved in the transfer of acyl groups, making it essential for processes like acetylation, protein modification, and energy production. It is widely used in laboratories to study metabolic pathways, enzyme reactions, and cofactor-dependent processes. Researchers in biochemistry and molecular biology rely on Coenzyme A Trilithium Salt to investigate cellular metabolism, enzyme kinetics, and lipid biosynthesis.
Cayman Chemical GunosIn 5-monphosphates 5g
A nucleotide that upon phosphorylation to GTP becomes incorporated into RNA; used to study modulation of glutamatergic neurotransmission
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.97% | 681.49 | 10 MM 1 ML
Sonidegib diphosphate is a potent and selective Smoothened (Smo) antagonist, inhibiting the Hedgehog (Hh) pathway. It has demonstrated antitumor activity in medulloblastoma models and can reduce chronic myeloid leukemia (CML) stem cells.
- Potent and selective Smo antagonist
- Inhibits Hedgehog pathway signaling
- Reduces expression of downstream signaling targets
- Demonstrates dose-related antitumor activity
- Reduces chronic myeloid leukemia stem cells
- Associated with numerous clinical trials
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 25mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research